Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.

ABSTRACT:

Rationale

The management of depression continues to be challenging despite the variety of available antidepressants. Herbal medicines are used in many cultures but lack stringent testing to understand their efficacy and mechanism of action. Isoalantolactone (LAT) from Elecampane (Inula helenium) improved the chronic social defeat stress (CSDS)-induced anhedonia-like phenotype in mice comparable to fluoxetine, a selective serotonin reuptake inhibitor (SSRI).

Objectives

Compare the effects of LAT and fluoxetine on depression-like behaviors in mice exposed to CSDS.

Result

The CSDS-induced decrease in protein expression of postsynaptic density (PSD95), brain derived neurotrophic factor (BDNF), and glutamate receptor subunit-1 (GluA1) in the prefrontal cortex was restored

SUBMITTER: Wang S 

PROVIDER: S-EPMC10349788 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature