Factors within the Developing Embryo and Ovarian Microenvironment That Influence Primordial Germ Cell Fate.

ABSTRACT:

Background

Primordial germ cell (PGC) fate is dictated by the designation, taxis, and influence of the surrounding embryonic somatic cells. Whereas gonadal sex determination results from a balance of factors within the tissue microenvironment.

Summary

Our understanding of mammalian ovary development is formed in large part from developmental time courses established using murine models. Genomic tools where genes implicated in the PGC designation or gonadal sex determination have been modulated through complete or conditional knockouts in vivo, and studies in in situ models with inhibitors or cultures that alter the native gonadal environment have pieced together the interplay of pioneering transcription factors, co-regulators and chromosomes critical for the progression of P

SUBMITTER: Laronda MM 

PROVIDER: S-EPMC10349905 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature