Defining Dementia Subtypes Through Neuropsychiatric Symptom-Linked Brain Connectivity Patterns.

ABSTRACT:

Background

Dementia is highly heterogeneous, with pronounced individual differences in neuropsychiatric symptoms (NPS) and neuroimaging findings. Understanding the heterogeneity of NPS and associated brain abnormalities is essential for effective management and treatment of dementia.

Methods

Using large-scale neuroimaging data from the Open Access Series of Imaging Studies (OASIS-3), we conducted a multivariate sparse canonical correlation analysis to identify functional connectivity-informed symptom dimensions. Subsequently, we performed a clustering analysis on the obtained latent connectivity profiles to reveal neurophysiological subtypes and examined differences in abnormal connectivity and phenotypic profiles between subtypes.

Results

We identified two reliable n

SUBMITTER: Zhao K 

PROVIDER: S-EPMC10349933 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature