Vaccination with Helicobacter pylori attachment proteins protects against gastric cancer.

ABSTRACT: Most cases of gastric cancer are caused by chronic Helicobacter pylori infection, but the lack of early onco-diagnostics and a high risk for antibiotic resistance hampers early intervention through eradication of H. pylori infection by antibiotics. We reported on a protective mechanism where H. pylori gastric mucosal attachment can be reduced by natural antibodies that block the binding of its attachment protein BabA. Here we show that challenge infection with H. pylori induced response of such blocking antibodies in both human volunteers and in rhesus macaques, that mucosal vaccination with BabA protein antigen induced blocking antibodies in rhesus macaques, and that vaccination in a mouse model induced blocking antibodies that reduced gastric mucosal inflammat

SUBMITTER: Bugaytsova JA 

PROVIDER: S-EPMC10349987 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature