Distinct features of the regenerating heart uncovered through comparative single-cell profiling.

ABSTRACT: Adult humans respond to heart injury by forming a permanent scar, yet other vertebrates are capable of robust and complete cardiac regeneration. Despite progress towards characterizing the mechanisms of cardiac regeneration in fish and amphibians, the large evolutionary gulf between mammals and regenerating vertebrates complicates deciphering which cellular and molecular features truly enable regeneration. To better define these features, we compared cardiac injury responses in zebrafish and medaka, two fish species that share similar heart anatomy and common teleost ancestry but differ in regenerative capability. We used single-cell transcriptional profiling to create a time-resolved comparative cell atlas of injury responses in all major cardiac cell types across both species. With this

SUBMITTER: Carey CM 

PROVIDER: S-EPMC10349989 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature