Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states.

ABSTRACT: The ability of a virus to infect a cell type is at least in part determined by the presence of host factors required for the viral life cycle. However, even within cell types that express known factors needed for infection, not every cell is equally susceptible, suggesting that our knowledge of the full spectrum of factors that promote infection is incomplete. Profiling the most susceptible subsets of cells within a population may reveal additional factors that promote infection. However, because viral infection dramatically alters the state of the cell, new approaches are needed to reveal the state of these cells prior to infection with virus. Here, we used single-cell clone tracing to retrospectively identify and characterize lung epithelial cells that are highly susceptible to infection

SUBMITTER: Reffsin S 

PROVIDER: S-EPMC10350037 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature