Ontology highlight
ABSTRACT:
SUBMITTER: Aviner R
PROVIDER: S-EPMC10350044 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20230706
A better mechanistic understanding of virus-host interactions can help reveal vulnerabilities and identify opportunities for therapeutic interventions. Of particular interest are essential interactions that enable production of viral proteins, as those could target an early step in the virus lifecycle. Here, we use subcellular proteomics, ribosome profiling analyses and reporter assays to detect changes in polysome composition and protein synthesis during SARS-CoV-2 (CoV2) infection. We identify ...[more]