Myeloid cell activation during Zika virus encephalitis predicts recovery of functional cortical connectivity.

ABSTRACT: Neurologic complications of Zika virus (ZIKV) infection across the lifespan have been described during outbreaks in Southeast Asia, South America, and Central America since 2016. In the adult CNS ZIKV tropism for neurons is tightly linked to its effects, with neuronal loss within the hippocampus during acute infection and protracted synapse loss during recovery, which is associated with cognitive deficits. The effects of ZIKV on cortical networks have not been evaluated. Although animal behavior assays have been used previously to model cognitive impairment, in vivo brain imaging can provide orthogonal information regarding the health of brain networks in real time, providing a tool to translate findings in animal models to humans. In this study, we use widefield optical imaging to measure

SUBMITTER: Agner SC 

PROVIDER: S-EPMC10350085 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature