Contribution of macrophages to intracochlear tissue remodeling responses following cochlear implantation and neural survival.

ABSTRACT:

Introduction

Cochlear implants (CIs) restore hearing to deafened patients. The foreign body response (FBR) following cochlear implantation (post-CI) comprises an infiltration of macrophages, other immune and non-immune cells, and fibrosis into the scala tympani; a space that is normally devoid of cells. This FBR is associated with negative effects on CI outcomes including increased electrode impedances and loss of residual acoustic hearing. This study investigates the extent to which macrophage depletion by an orally administered CSF-1R specific kinase (c-FMS) inhibitor, PLX-5622, modulates the tissue response to CI and neural health.

Materials and methods

10-12-week-old CX3CR1+/GFP Thy1+/YFP mice on C57Bl6 background with normal hearing were fed chow containing 1200 mg/kg P

SUBMITTER: Rahman MT 

PROVIDER: S-EPMC10350110 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature