Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.

ABSTRACT: The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we investigated the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of BP. First, we assessed the association of a large collection of immune-related genes (4,925) with Li response, defined by the Retrospective Assessment of the Lithium Response Phenotype Scale (Alda scale), and clinical characteristics in patients with BP from the International Consortium on Lithium Genetics (ConLi⁺Gen, N = 2,374). Second, we calculated here previously published polygenic scores (PGSs) f

SUBMITTER: Herrera-Rivero M 

PROVIDER: S-EPMC10350128 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature