Maternal prenatal immune activation associated with brain tissue microstructure and metabolite concentrations in newborn infants.

ABSTRACT:

Importance

Few translational human studies have assessed the association of prenatal maternal immune activation with altered brain development and psychiatric risk in newborn offspring.

Objective

To identify the effects of maternal immune activation during the 2^nd and 3^rd trimesters of pregnancy on newborn brain metabolite concentrations, tissue microstructure, and longitudinal motor development.

Design

Prospective longitudinal cohort study conducted from 2012 - 2017.

Setting

Columbia University Irving Medical Center and Weill Cornell Medical College.

Participants

76 nulliparous pregnant women, aged 14 to 19 years, were recruited in their 2^nd trimester, and their children were followed through 14 months of age.

Exposur

SUBMITTER: Spann MN 

PROVIDER: S-EPMC10350159 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature