Early HIV-1 Gag Assembly on Lipid Membrane with vRNA.

ABSTRACT: HIV-1 capsid assembly is an essential process in the virus infection cycle. Initiation of capsid assembly involves viral proteins, genomic RNA, and the inner leaflet of the plasma membrane, facilitated by a number of cellular factors ¹ . The viral structural protein Gag plays a 10 number of central roles in this process, including association with the membrane, selective binding of genomic RNA, and oligomerization and packaging to ultimately produce an immature budded pro-viral particle ² . While there have been intensive studies regarding the early stages of Gag assembly, there is a lack of consensus on the mechanism for nucleation and growth of Gag complexes ^3-7 . Here we show that myristoylated Gag forms a trimer nucleus in a model 15 membrane that can s

SUBMITTER: Williamson J 

PROVIDER: S-EPMC10350206 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature