Transcriptional programming of CD4⁺ T_RM differentiation in viral infection balances effector- and memory-associated gene expression.

ABSTRACT: After resolution of infection, T cells differentiate into long-lived memory cells that recirculate through secondary lymphoid organs or establish residence in tissues. In contrast to CD8⁺ tissue-resident memory T cells (T_RM), the developmental origins and transcriptional regulation of CD4⁺ T_RM remain largely undefined. Here, we investigated the phenotypic, functional, and transcriptional profiles of CD4⁺ T_RM in the small intestine (SI) responding to acute viral infection, revealing a shared gene expression program and chromatin accessibility profile with circulating T_H1 and the progressive acquisition of a mature T_RM program. Single-cell RNA sequencing identified heterogeneity among established CD4

SUBMITTER: Nguyen QP 

PROVIDER: S-EPMC10350289 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature