Exploration and Validation of Potential Biomarkers and Therapeutic Targets in Ferroptosis of Asthma.

ABSTRACT:

Purpose

Asthma is a chronic inflammatory airway disease involving multiple mechanisms, of which ferroptosis is a form of programmed cell death. Recent studies have shown that ferroptosis may play a crucial role in the pathogenesis of asthma, but no specific ferroptosis gene has been found in asthma, and the exact mechanism is still unclear. The present study aimed to screen ferroptosis genes associated with asthma and find therapeutic targets, in order to contribute a new clue for the diagnosis and therapy of asthma.

Methods

Ferroptosis-related differentially expressed genes (FR-DEGs) in asthma were selected by the GSE41861, GSE43696 and ferroptosis datasets. Next, the FR-DEGs were subjected by GO and KEGG enrichment, and the mRNA-miRNA network was constructed. Then, GSEA an

SUBMITTER: Xing Y 

PROVIDER: S-EPMC10350417 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature