Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest.

ABSTRACT:

Background

Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome profiles from unconscious patients admitted to hospital after out-of-hospital cardiac arrest according to temperature treatment and neurological outcome.

Methods

Serum samples at 24, 48, and 72 h after cardiac arrest at three centres included in the Target Temperature Management after out-of-hospital cardiac arrest trial underwent data-independent acquisition mass spectrometry analysi

SUBMITTER: Lileikyte G 

PROVIDER: S-EPMC10350448 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature