Identification and validation of six acute myocardial infarction-associated variants, including a novel prognostic marker for cardiac mortality.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is one of the leading causes of death worldwide, and approximately half of AMI-related deaths occur before the affected individual reaches the hospital. The present study aimed to identify and validate genetic variants associated with AMI and their role as prognostic markers.

Materials and methods

We conducted a replication study of 29 previously identified novel loci containing 85 genetic variants associated with early-onset AMI using a new independent set of 2,920 Koreans [88 patients with early- and 1,085 patients with late-onset AMI, who underwent percutaneous coronary intervention (PCI), and 1,747 healthy controls].

Results

Of the 85 previously reported early-onset variants, six were confirmed in our genome-wide associ

SUBMITTER: Jeon Y 

PROVIDER: S-EPMC10350496 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature