A critical evaluation of QIDS-SR-16 using data from a trial of psilocybin therapy versus escitalopram treatment for depression.

ABSTRACT:

Background

In a recent clinical trial examining the comparative efficacy of psilocybin therapy (PT) versus escitalopram treatment (ET) for major depressive disorder, 14 of 16 major efficacy outcome measures yielded results that favored PT, but the Quick Inventory of Depressive Symptomatology, Self-Report, 16 items (QIDS-SR₁₆) did not.

Aims

The present study aims to (1) rationally and psychometrically account for discrepant results between outcome measures and (2) to overcome psychometric problems particular to individual measures by re-examining between-condition differences in depressive response using all outcome measures at item-, facet-, and factor-levels of analysis.

Method

Four depression measures were compared on the basis of their validity for exami

SUBMITTER: Weiss B 

PROVIDER: S-EPMC10350722 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature