Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization.

ABSTRACT: The paucity of blood granulocyte populations such as neutrophils in laboratory mice is a notable difference between this model organism and humans, but the cause of this species-specific difference is unclear. We previously demonstrated that laboratory mice released into a seminatural environment, referred to as rewilding, display an increase in blood granulocytes that is associated with expansion of fungi in the gut microbiota. Here, we find that tonic signals from fungal colonization induce sustained granulopoiesis through a mechanism distinct from emergency granulopoiesis, leading to a prolonged expansion of circulating neutrophils that promotes immunity. Fungal colonization after either rewilding or oral inoculation of laboratory mice with Candida albicans induced persistent exp

SUBMITTER: Chen YH 

PROVIDER: S-EPMC10350741 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature