Genetic markers of children asthma: predisposition to disease course variants.

ABSTRACT: Asthma is a heterogeneous and often difficult to treat condition that results in a disproportionate cost to healthcare systems. Children with severe asthma are at increased risk for adverse outcomes including medication-related side effects, life-threatening exacerbations, and impaired quality of life. An important therapeutic focus is to achieve disease control, which is supposed to involve a personalized approach to treatment of asthma of any severity. Asthma is a multifactorial disease with a significant genetic determinant, however, the inheritance of asthma has not been fully elucidated. Polymorphic genes of inflammatory mediators, including cytokines, play an important role in developing various disease forms. In the current study, large-scale original data on the prevalence of cytok

SUBMITTER: Smolnikova MV 

PROVIDER: S-EPMC10350864 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature