Aging in nucleus accumbens and its impact on alcohol use disorders.

ABSTRACT: Ethanol is one of the most widely consumed drugs in the world and prolonged excessive ethanol intake might lead to alcohol use disorders (AUDs), which are characterized by neuroadaptations in different brain regions, such as in the reward circuitry. In addition, the global population is aging, and it appears that they are increasing their ethanol consumption. Although research involving the effects of alcohol in aging subjects is limited, differential effects have been described. For example, studies in human subjects show that older adults perform worse in tests assessing working memory, attention, and cognition as compared to younger adults. Interestingly, in the field of the neurobiological basis of ethanol actions, there is a significant dichotomy between what we know about the effects

SUBMITTER: Konar-Nie M 

PROVIDER: S-EPMC10350931 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature