Genomic alterations related to HPV infection status in a cohort of Chinese prostate cancer patients.

ABSTRACT:

Background

Human papillomavirus (HPV) has been proposed as a potential pathogenetic organism involved in prostate cancer (PCa), but the association between HPV infection and relevant genomic changes in PCa is poorly understood.

Methods

To evaluate the relationship between HPV genotypes and genomic alterations in PCa, HPV capture sequencing of DNA isolated from 59 Han Chinese PCa patients was performed using an Illumina HiSeq2500. Additionally, whole-exome sequencing of DNA from these 59 PCa tissue samples and matched normal tissues was carried out using the BGI DNBSEQ platform. HPV infection status and genotyping were determined, and the genetic disparities between HPV-positive and HPV-negative PCa were evaluated.

Results

The presence of the high-risk HPV genome was i

SUBMITTER: Lang B 

PROVIDER: S-EPMC10351112 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature