Sizes and shapes of perivascular spaces surrounding murine pial arteries.

ABSTRACT:

Background

Flow of cerebrospinal fluid (CSF) through brain perivascular spaces (PVSs) is essential for the clearance of interstitial metabolic waste products whose accumulation and aggregation is a key mechanism of pathogenesis in many diseases. The PVS geometry has important implications for CSF flow as it affects CSF and solute transport rates. Thus, the size and shape of the perivascular spaces are essential parameters for models of CSF transport in the brain and require accurate quantification.

Methods

We segmented two-photon images of pial (surface) PVSs and the adjacent arteries and characterized their sizes and shapes of cross sections from 14 PVS segments in 9 mice. Based on the analysis, we propose an idealized model that approximates the cross-sectional size and sh

SUBMITTER: Raicevic N 

PROVIDER: S-EPMC10351203 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature