Copper metabolism in cell death and autophagy.
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ABSTRACT:
SUBMITTER: Xue Q
PROVIDER: S-EPMC10351475 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Publications
Copper metabolism in cell death and autophagy.
Xue Qian Q Kang Rui R Klionsky Daniel J DJ Tang Daolin D Liu Jinbao J Chen Xin X
Autophagy 20230416 8
Copper is an essential trace element in biological systems, maintaining the activity of enzymes and the function of transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as apoptosis, paraptosis, pyroptosis, ferroptosis, and cuproptosis. Furthermore, copper ions can trigger macroautophagy/autophagy, a lysosome-dependent degradation pathway that plays a dual role in regulating the survival or death fate of cells under va ...[more]
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