Quantification of Curvature Sensing Behavior of Curvature-Inducing Proteins on Model Wavy Substrates.

ABSTRACT: Curvature-inducing proteins are involved in a variety of membrane remodeling processes in the cell. Several in vitro experiments have quantified the curvature sensing behavior of these proteins in model lipid systems. One such system consists of a membrane bilayer laid atop a wavy substrate (Hsieh in Langmuir 28:12838-12843, 2012). In these experiments, the bilayer conforms to the wavy substrate, and curvature-inducing proteins show preferential segregation on the wavy membrane. Using a mesoscale computational membrane model based on the Helfrich Hamiltonian, here we present a study which analyzes the curvature sensing characteristics of this membrane-protein system, and elucidates key physical principles governing protein segregation on the wavy substrate and other in vitro systems. In th

SUBMITTER: Tourdot RW 

PROVIDER: S-EPMC10351602 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature