Cis-regulatory Landscape Size, Constraint, and Tissue Specificity Associate with Gene Function and Expression.

ABSTRACT: Multiple distal cis-regulatory elements (CREs) often cooperate to regulate gene expression, and the presence of multiple CREs for a gene has been proposed to provide redundancy and robustness to variation. However, we do not understand how attributes of a gene's distal CRE landscape-the CREs that contribute to its regulation-relate to its expression and function. Here, we integrate three-dimensional chromatin conformation and functional genomics data to quantify the CRE landscape composition genome-wide across ten human tissues and relate their attributes to the function, constraint, and expression patterns of genes. Within each tissue, we find that expressed genes have larger CRE landscapes than nonexpressed genes and that genes with tissue-specific CREs are more likely to have tissue-spe

SUBMITTER: Benton ML 

PROVIDER: S-EPMC10351668 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature