Optimizing antiretroviral therapy for children living with HIV: Experience from an observational cohort in Lesotho.

ABSTRACT:

Introduction

We describe transition of HIV-positive children from efavirenz- or nevirapine-based antiretroviral therapy (ART) to optimal dolutegravir (DTG) or lopinavir/ritonavir (LPV/r) (solid formulation)-based ART in Lesotho.

Methods

We followed a cohort of children less than 15 years of age who were initiated on ART on or after January 1, 2018 from 21 selected health facilities in Lesotho. From March 2020 to May 2022, we collected data retrospectively through chart abstraction and prospectively through caregiver interviews to cover a period of 24 months following treatment initiation. We used a structured questionnaire to collect data on demographics, ART regimen, drug formulations and switches, viral suppression, retention, and drug administration challenges. Data were

SUBMITTER: Tukei VJ 

PROVIDER: S-EPMC10351696 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature