Impact of airway challenges on cardiovascular risk in asthma - a randomized controlled trial.

ABSTRACT:

Background

People experiencing asthma exacerbations are at increased risk of cardiovascular events. To better understand the relationship between asthma exacerbations and cardiovascular risk, this randomized case-control, cross-over controlled trial assessed the immediate systemic inflammatory and vascular responses to acutely induced pulmonary inflammation and bronchoconstriction in people with asthma and controls.

Methods

Twenty-six people with asthma and 25 controls underwent three airway challenges (placebo, mannitol, and methacholine) in random order. Markers of cardiovascular risk, including serum C-reactive protein, interleukin-6, and tumor necrosis factor, endothelial function (flow-mediated dilation), microvascular function (blood-flow following reactive hyperemia),

SUBMITTER: Moore LE 

PROVIDER: S-EPMC10351735 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature