Mutational profiling of Chinese patients with thyroid cancer.

ABSTRACT:

Background

The incidence of thyroid cancer in China has rapidly increased in recent decades. As the genetic profiles of thyroid cancer vary dramatically between different geographical regions, a comprehensive genetic landscape of thyroid cancer in the Chinese population is urgently needed.

Methods

We retrospectively included thyroid cancer patients from three Chinese medical centers between February 2015 and August 2020. To dissect the genomic profiling of these patients, we performed targeted next-generation sequencing on their tumor tissues using a 1,021-gene panel.

Results

A total of 458 Chinese patients with thyroid cancer were enrolled, including four malignant histological subtypes arising from follicular epithelial thyroid cells. BRAF driver mutations we

SUBMITTER: Du Y 

PROVIDER: S-EPMC10351985 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature