Staphylococci planktonic and biofilm environments differentially affect osteoclast formation.

ABSTRACT:

Introduction

The pathophysiology of chronic implant-related bone infections is characterized by an increase in osteoclast numbers and enhanced bone resorption. Biofilms are a major reason for chronicity of such infections as the biofilm matrix protects bacteria against antibiotics and impairs the function of immune cells. Macrophages are osteoclast precursor cells and therefore linked to inflammation and bone destruction.

Objective and method

Investigations on the impact of biofilms on the ability of macrophages to form osteoclasts are yet missing and we, therefore, analyzed the effect of Staphylococcus aureus (SA) and Staphylococcus epidermidis (SE) planktonic and biofilm environments on osteoclastogenesis using RAW 264.7 cells and conditioned media (CM).

Results

Pri

SUBMITTER: Seebach E 

PROVIDER: S-EPMC10352167 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature