Automated radiosynthesis and in vivo evaluation of ¹⁸F-labeled analog of the photosensitizer ADPM06 for planning photodynamic therapy.

ABSTRACT:

Background

A family of BF₂-chelated tetraaryl-azadipyrromethenes was developed as non-porphyrin photosensitizers for photodynamic therapy. Among the developed photosensitizers, ADPM06 exhibited excellent photochemical and photophysical properties. Molecular imaging is a useful tool for photodynamic therapy planning and monitoring. Radiolabeled photosensitizers can efficiently address photosensitizer biodistribution, providing helpful information for photodynamic therapy planning. To evaluate the biodistribution of ADPM06 and predict its pharmacokinetics on photodynamic therapy with light irradiation immediately after administration, we synthesized [¹⁸F]ADPM06 and evaluated its in vivo properties.

Results

[¹⁸F]ADPM06 was automatically synthesi

SUBMITTER: Kawamura K 

PROVIDER: S-EPMC10352184 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature