Comparison of Biological Characteristics of Human Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells from Extremely Preterm and Term Infants.

ABSTRACT:

Background

Despite the progress in perinatal-neonatal medicine, complications of extremely preterm infants continue to constitute the major adverse outcomes in neonatal intensive care unit. Human umbilical cord Wharton's Jelly-derived mesenchymal stem cells (HUMSCs) may offer new hope for the treatment of intractable neonatal disorders. This study will explore the functional differences of HUMSCs between extremely preterm and term infants.

Methods

UMSCs from 5 extremely preterm infants(weeks of gestation: 22⁺⁵ w,24⁺⁴ w,25⁺³ w,26 w,28 w) and 2 term infants(39 w,39⁺² w) were isolated, and mesenchymal markers, pluripotent genes, proliferation rate were analyzed. HUVECs were injured by treated with LPS and repaired by co-cultured with

SUBMITTER: Huang P 

PROVIDER: S-EPMC10352204 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature