Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling.

ABSTRACT: More Americans are consuming diets higher in saturated fats and refined sugars than ever before. These trends could have serious consequences for the older population because high-fat diet (HFD) consumption, known to induce neuroinflammation, has been shown to accelerate and aggravate memory declines. We have previously demonstrated that short-term HFD consumption, which does not evoke obesity-related comorbidities, produced profound impairments to hippocampal-dependent memory in aged rats. These impairments were precipitated by increases in proinflammatory cytokines, primarily interleukin-1 beta (IL-1β). Here, we explored the extent to which short-term HFD consumption disrupts hippocampal synaptic plasticity, as measured by long-term potentiation (LTP), in young adult and aged rats. We de

SUBMITTER: Gonzalez Olmo BM 

PROVIDER: S-EPMC10352252 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature