Severe COVID-19 associated hyperglycemia is caused by beta cell dysfunction: a prospective cohort study.

ABSTRACT:

Background

COVID-19, an infectious disease caused by SARS-CoV-2, was shown to be associated with an increased risk of new-onset diabetes. Mechanisms contributing to the development of hyperglycemia are still unclear. We aimed to study whether hyperglycemia is related to insulin resistance and/or beta cell dysfunction.

Materials and methods

Survivors of severe COVID-19 but without a known history of diabetes were examined at baseline (T0) and after 3 (T3) and 6 (T6) months: corticosteroids use, indirect calorimetry, and OGTT. Insulin response and sensitivity (IS) were expressed as insulinogenic (IGI), disposition (DI), and Matsuda insulin sensitivity index (ISI). Resting energy expenditure (REE) and respiratory quotient (RQ) was calculated from the gas exchange and nitrogen l

SUBMITTER: Gojda J 

PROVIDER: S-EPMC10352285 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature