AraC interacts with p75^NTR transmembrane domain to induce cell death of mature neurons.

ABSTRACT: Cytosine arabinoside (AraC) is one of the main therapeutic treatments for several types of cancer, including acute myeloid leukaemia. However, after a high-dose AraC chemotherapy regime, patients develop severe neurotoxicity and cell death in the central nervous system leading to cerebellar ataxia, dysarthria, nystagmus, somnolence and drowsiness. AraC induces apoptosis in dividing cells. However, the mechanism by which it leads to neurite degeneration and cell death in mature neurons remains unclear. We hypothesise that the upregulation of the death receptor p75^NTR is responsible for AraC-mediated neurodegeneration and cell death in leukaemia patients undergoing AraC treatment. To determine the role of AraC-p75^NTR signalling in the cell death of mature neurons, we us

SUBMITTER: Lopes-Rodrigues V 

PROVIDER: S-EPMC10352303 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature