Gallium-68 labelled RGD PET/CT imaging of endothelial activation in COVID-19 patients.

ABSTRACT: In coronavirus disease 2019 (COVID-19), endothelial cells play a central role and an inadequate response is associated with vascular complications. PET imaging with gallium-68 labelled RGD-peptide (⁶⁸Ga-RGD) targets α_vβ₃ integrin expression which allows quantification of endothelial activation. In this single-center, prospective observational study, we included ten hospitalized patients with COVID-19 between October 2020 and January 2021. Patients underwent ⁶⁸Ga-RGD PET/CT followed by iodine mapping of lung parenchyma. CT-based segmentation of lung parenchyma, carotid arteries and myocardium was used to quantify tracer uptake by calculating standardized uptake values (SUV). Five non-COVID-19 patients were used as reference. The study population w

SUBMITTER: van Genugten EAJ 

PROVIDER: S-EPMC10352333 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature