Ontology highlight
ABSTRACT:
SUBMITTER: Koncina E
PROVIDER: S-EPMC10352362 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Koncina E E Nurmik M M Pozdeev V I VI Gilson C C Tsenkova M M Begaj R R Stang S S Gaigneaux A A Weindorfer C C Rodriguez F F Schmoetten M M Klein E E Karta J J Atanasova V S VS Grzyb K K Ullmann P P Halder R R Hengstschläger M M Graas J J Augendre V V Karapetyan Y E YE Kerger L L Zuegel N N Skupin A A Haan S S Meiser J J Dolznig H H Letellier E E
Nature communications 20230717 1
Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1<sup>+</sup>, IL-1-high-signaling subtype of fibroblasts, using multiple colorectal cancer (CRC) patient single cell sequencing datasets. This subtype of fibroblasts is linked to T cell and macrophage suppression and leads to increased cancer cell growth in 3D co-culture assays. Furthermore, both a fibroblast-specific IL1R1 knock ...[more]