Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF).

ABSTRACT: Cellular senescence is involved in the development of pulmonary fibrosis as well as in lung tissue repair and regeneration. Therefore, a strategy of removal of senescent cells by senolytic drugs may not produce the desired therapeutic result. Previously we reported that tyrosine kinase Fgr is upregulated in ionizing irradiation-induced senescent cells. Inhibition of Fgr reduces the production of profibrotic proteins by radiation-induced senescent cells in vitro; however, a mechanistic relationship between senescent cells and radiation-induced pulmonary fibrosis (RIPF) has not been established. We now report that senescent cells from the lungs of mice with RIPF, release profibrotic proteins for target cells and secrete chemotactic proteins for marrow cells. The Fgr inhibitor TL02-59, reduce

SUBMITTER: Mukherjee A 

PROVIDER: S-EPMC10352363 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature