Clinical value of cholinesterase in patients treated with radical nephroureterectomy for upper urinary tract carcinoma.

ABSTRACT:

Purpose

To evaluate the prognostic value and the clinical impact of preoperative serum cholinesterase (ChoE) levels on decision-making in patients treated with radical nephroureterectomy (RNU) for clinically non-metastatic upper tract urothelial cancer (UTUC).

Methods

A retrospective review of an established multi-institutional UTUC database was performed. We evaluated preoperative ChoE as a continuous and dichotomized variable using a visual assessment of the functional form of the association of ChoE with cancer-specific survival (CSS). We used univariable and multivariable Cox regression models to establish its association with recurrence-free survival (RFS), CSS, and overall survival (OS). Discrimination was evaluated using Harrell's concordance index. Decision curve ana

SUBMITTER: von Deimling M 

PROVIDER: S-EPMC10352439 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature