PTEN-induced kinase 1 is associated with renal aging, via the cGAS-STING pathway.

ABSTRACT: Mitochondrial dysfunction is considered to be an important mediator of the pro-aging process in chronic kidney disease, which is continuously increasing worldwide. Although PTEN-induced kinase 1 (PINK1) regulates mitochondrial function, its role in renal aging remains unclear. We investigated the association between PINK1 and renal aging, especially through the cGAS-STING pathway, which is known to result in an inflammatory phenotype. Pink1 knockout (Pink1^-/- ) C57BL/6 mice and senescence-induced renal tubular epithelial cells (HKC-8) treated with H₂ O₂ were used as the renal aging models. Extensive analyses at transcriptomic-metabolic levels have explored changes in mitochondrial function in PINK1 deficiency. To investigate whether PINK1 deficiency affects

SUBMITTER: Ha MH 

PROVIDER: S-EPMC10352563 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature