Single-cell landscape analysis reveals systematic senescence in mammalian Down syndrome.

ABSTRACT:

Background

Down syndrome (DS), which is characterized by various malfunctions, is the most common chromosomal disorder. As the DS population continues to grow and most of those with DS live beyond puberty, early-onset health problems have become apparent. However, the cellular landscape and molecular alterations have not been thoroughly studied.

Methods

This study utilized single-cell resolution techniques to examine DS in humans and mice, spanning seven distinct organs. A total of 71 934 mouse and 98 207 human cells were analyzed to uncover the molecular alterations occurring in different cell types and organs related to DS, specifically starting from the fetal stage. Additionally, SA-β-Gal staining, western blot, and histological study were employed to verify the alteratio

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10352595 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature