The combination of NDUFS1 with CD4⁺ T cell infiltration predicts favorable prognosis in kidney renal clear cell carcinoma.

ABSTRACT: Background: Kidney renal clear cell carcinoma (KIRC) is an immunogenic tumor, and immune infiltrates are relevant to patients' therapeutic response and prognosis. NDUFS1, the core subunit of mitochondrial complex I, has been reported to be associated with KIRC patients' prognosis. However, the upstream regulator for NDUFS1 and their correlations with immune infiltration remain unclear. Methods: The expression of NDUFS genes in KIRC and their influences on patients' survival were investigated by UALCAN, ENCORI, Oncomine, TIMER as well as Kaplan-Meier Plotter. miRNAs regulating NDUFS1 were predicted and analyzed by TargetScan and ENCORI. The correlations between NDUFS1 expression and immune cell infiltration or gene marker sets of immune infil

SUBMITTER: Wu D 

PROVIDER: S-EPMC10352660 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature