Identification of key genes and therapeutic drugs for cocaine addiction using integrated bioinformatics analysis.

ABSTRACT:

Introduction

Cocaine is a highly addictive drug that is abused due to its excitatory effect on the central nervous system. It is critical to reveal the mechanisms of cocaine addiction and identify key genes that play an important role in addiction.

Methods

In this study, we proposed a centrality algorithm integration strategy to identify key genes in a protein-protein interaction (PPI) network constructed by deferential genes from cocaine addiction-related datasets. In order to investigate potential therapeutic drugs for cocaine addiction, a network of targeted relationships between nervous system drugs and key genes was established.

Results

Four key genes (JUN, FOS, EGR1, and IL6) were identified and well validated using CTD database correlation analysis, text mining

SUBMITTER: Wang X 

PROVIDER: S-EPMC10352680 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature