GtAI: an improved species-specific tRNA adaptation index using the genetic algorithm.

ABSTRACT: The tRNA adaptation index (tAI) is a translation efficiency metric that considers weighted values (S _ij values) for codon-tRNA wobble interaction efficiencies. The initial implementation of the tAI had significant flaws. For instance, generated S _ij weights were optimized based on gene expression in Saccharomyces cerevisiae, which is expected to vary among different species. Consequently, a species-specific approach (stAI) was developed to overcome those limitations. However, the stAI method employed a hill climbing algorithm to optimize the S _ij weights, which is not ideal for obtaining the best set of S _ij weights because it could struggle to find the global maximum given a complex

SUBMITTER: Anwar AM 

PROVIDER: S-EPMC10352787 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature