Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms.

ABSTRACT:

Aims

In this study, we aimed to investigate the effect of neuropsychiatric symptoms (NPS) on the rate of cognitive decline for both global cognition and specific cognitive domains in a cohort of patients from the Parkinson's Progression Markers Initiative (PPMI).

Method

Prospectively longitudinal data were obtained from the PPMI cohort. NPS, including depression, anxiety, apathy, psychosis, impulse control disorders (ICDs), and cognition ability, were evaluated by a series of questionnaires. Linear mixed-effects models were used to investigate the relationship between NPS and the rate of cognitive decline. Generalized estimating equations (GEEs) were used to investigate the relationship between NPS and the occurrence of mild cognitive impairment (MCI).

Results

In tota

SUBMITTER: Meng D 

PROVIDER: S-EPMC10352866 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature