Deep brain stimulation improves central nervous system inflammation in Parkinson's disease: Evidence and perspectives.

ABSTRACT:

Background

In Parkinson's disease (PD), inflammation may lead to the degeneration of dopaminergic (DAergic) neurons. Previous studies showed that inflammatory mediators mainly contributed to this phenomenon. On the other hand, invasive neuromodulation methods such as deep brain stimulation (DBS) have better therapeutic effects for PD. One possibility is that DBS improves PD by influencing inflammation. Therefore, we further explored the mechanisms underlying inflammatory mediators and DBS in the pathogenesis of PD.

Methods

We measured serum levels of two inflammatory markers, namely RANTES (regulated on activation, normal T cell expressed and secreted) and tumor necrosis factor-alpha (TNF-α), using Luminex assays in 109 preoperative DBS PD patients, 49 postoperative DBS PD p

SUBMITTER: Chang L 

PROVIDER: S-EPMC10352870 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature