Acetylated α-tubulin alleviates injury to the dendritic spines after ischemic stroke in mice.

ABSTRACT:

Background and aim

Functional recovery is associated with the preservation of dendritic spines in the penumbra area after stroke. Previous studies found that polymerized microtubules (MTs) serve a crucial role in regulating dendritic spine formation and plasticity. However, the mechanisms that are involved are poorly understood. This study is designed to understand whether the upregulation of acetylated α-tubulin (α-Ac-Tub, a marker for stable, and polymerized MTs) could alleviate injury to the dendritic spines in the penumbra area and motor dysfunction after ischemic stroke.

Methods

Ischemic stroke was mimicked both in an in vivo and in vitro setup using middle cerebral artery occlusion and oxygen-glucose deprivation models. Thy1-YFP mice were utilized to observe the morpho

SUBMITTER: Yang C 

PROVIDER: S-EPMC10352872 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature