Reactive astrocytes targeting with oral vitamin A: Efficient neuronal regeneration for Parkinson's disease treatment and reversal of associated liver fibrosis.

ABSTRACT:

Introduction

A recent approach to cure neurodegenerative diseases is to reprogram fibroblasts into functioning neurons using multiple exogenous transcription factors (TFs) and micro-RNAs. Administering agents that can endogenously induce these TFs may bypass the limitations of this approach. Astrocytes may represent a part of the extrahepatic-stellate system involved in vitamin-A (V_A ) homeostasis. Activated-stellate cells lose their V_A -storage capacity, and this was previously applied for hepatic-stellate cells (HSCs) targeting to treat liver fibrosis. Accordingly, it is hypothesized that Parkinson's disease (PD) may be coupled with retinoid depletion that may extract V_A from V_A -rich-HSCs triggering liver fibrosis. Thus, V_A

SUBMITTER: El-Mezayen NS 

PROVIDER: S-EPMC10352881 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature