Multiparametric mapping of white matter reorganizations in patients with frontal glioma-related epilepsy.

ABSTRACT:

Aims

Epilepsy is a common symptom in diffuse lower-grade glioma (DLGG). The specific role of white matter (WM) alteration in patients with glioma-related epilepsy (GRE) is largely unknown. This study aims to investigate the reorganization of WM tracts and changes in structural networks related to GRE.

Methods

Diffusion-weighted images were collected from 70 patients with left frontal DLGG (GRE = 33, non-GRE = 37) and 41 healthy controls (HC). Tractometry with TractSeg was applied to segment tracts and quantify fractional anisotropy (FA) along each tract. Structural network was constructed using constrained spherical deconvolution and probabilistic tractography. FA and network properties were compared among three groups.

Results

Compared with HC, both GRE and non-GRE s

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10352885 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature