Causal association between serum total bilirubin and cholelithiasis: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies about the association between serum total bilirubin and cholelithiasis are inconsistent. Hence, it is essential to reevaluate the association between serum total bilirubin and cholelithiasis and to verify whether such association is causal or not.

Methods

We selected single-nucleotide polymorphisms (SNPs) that are strongly associated with exposure as instrumental variable and conducted a bidirectional two-sample Mendelian randomization (MR) study to explore the causal association between serum total bilirubin and cholelithiasis. We implemented the inverse-variance weighted approach as a primary analysis to combine the Wald ratio estimates. Four additional analyses, namely, MR-Egger regression, weighted median, weighted mode, and MR-pleiotropy

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10352914 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature