Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial.

ABSTRACT:

Importance

Fewer than 5% of patients labeled with a penicillin allergy are truly allergic. The standard of care to remove the penicillin allergy label in adults is specialized testing involving prick and intradermal skin testing followed by an oral challenge with penicillin. Skin testing is resource intensive, limits practice to specialist-trained physicians, and restricts the global population who could undergo penicillin allergy delabeling.

Objective

To determine whether a direct oral penicillin challenge is noninferior to the standard of care of penicillin skin testing followed by an oral challenge in patients with a low-risk penicillin allergy.

Design, setting, and participants

This parallel, 2-arm, noninferiority, open-label, multicenter, international randomized

SUBMITTER: Copaescu AM 

PROVIDER: S-EPMC10352926 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature